Question: X | G Active transport is ach. Course Home Problem Set on.com/eplayer/book/7)P44HNBIAK/page/a45 P…


x | G Active transport is ach. Course Home Problem Set on.com/eplayer/book/7)P44HNBIAK/page/a45 Problem Set Q A A 7-10 HYDROPATHY: THE PLOT THICKENS. A hydropathy plot can be used to predict the structure of a membrane protein based on its amino acid sequence and the hydrophobicity values of the amino acids. Hydrophobicity is measured as the standard free energy change, AG, for the transter of a given amino acid residue from a hydrophoble solvent into water, in kilojoules per mole (k3/mol). The hydropathy index is calculated by averaging the hydrophobicity values for a serles of short segments of the polypeptide, with each segment displaced one amino acid arther from the N-terminus. The hydropathy index of each successive segment is then plotted as a function of the location of that segment in the amino acld sequence, and the plot is examined for regions of high hydropathy index a. Why do scientists try to predict the structure of a membrane protein by this indirect means when the technique of X-ray crystallography would reveal the structure directly b. Given the way it is defined, would you expect the hydrophobicity index of a hydrophobic reaidue such as valine or Isoleucine to be posltive or negative? What about a hydrophilic residue such as aspartic acid or arginine? c. Listed below are four amino aclds and four hydrophobicity values. Match the hydrophobicity values with the correct amino acids, and expiain your reasoning 5 6 8 9

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x | G Active transport is ach. Course Home Problem Set on.com/eplayer/book/7)P44HNBIAK/page/a45 Problem Set Q A A 7-10 HYDROPATHY: THE PLOT THICKENS. A hydropathy plot can be used to predict the structure of a membrane protein based on its amino acid sequence and the hydrophobicity values of the amino acids. Hydrophobicity is measured as the standard free energy change, AG, for the transter of a given amino acid residue from a hydrophoble solvent into water, in kilojoules per mole (k3/mol). The hydropathy index is calculated by averaging the hydrophobicity values for a serles of short segments of the polypeptide, with each segment displaced one amino acid arther from the N-terminus. The hydropathy index of each successive segment is then plotted as a function of the location of that segment in the amino acld sequence, and the plot is examined for regions of high hydropathy index a. Why do scientists try to predict the structure of a membrane protein by this indirect means when the technique of X-ray crystallography would reveal the structure directly b. Given the way it is defined, would you expect the hydrophobicity index of a hydrophobic reaidue such as valine or Isoleucine to be posltive or negative? What about a hydrophilic residue such as aspartic acid or arginine? c. Listed below are four amino aclds and four hydrophobicity values. Match the hydrophobicity values with the correct amino acids, and expiain your reasoning 5 6 8 9

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