Question: Pyruvate dehydrogenase Complex (PDHC) is an enzyme complex that
you are very familiar with. You k…


Pyruvate dehydrogenase Complex (PDHC) is an enzyme complex that
you are very familiar with. You know it is a highly regulated,
multi-enzyme complex just outside of the TCA cycle. PDHC requires 4
B-vitamins and lipoic acid. (a) What are the substrates and
products of the overall PDHC reaction? (b) Name the vitamin and
activated form of each vitamin that acts as a coenzyme. (c) We
discussed the details of activation for 3 of the 4 vitamin
coenzymes in class. Name one biochemical change that occurs leading
to its active form. (d) How are each of the five PDHC coenzymes
regenerated?

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