Question: Knowing that the genetic code is generally considered universal,
a scientist uses biotechnology t…


Knowing that the genetic code is generally considered universal,
a scientist uses biotechnology to insert a human DNA gene for
beta-globin into E. coli cells. He is certain that the bacterial
cells will express and synthesize functional beta-globin.
Beta-globin is one of the proteins used to form the oxygen-carrying
hemoglobin protein (a quaternary structure) and could be used to
help patients with abnormal hemoglobin. Instead, the protein
produced by the bacteria is larger and non-functional. Upon further
investigation it was found to have a different shape with a
different sequence of amino acids than the normal protein.

Question:

With your knowledge of DNA, the genetic code, and
protein synthesis, try to explain why the proper human gene for the
beta-globin that was inserted into the bacteria might not have
produced the correct shape and sequence of amino acids and why the
protein formed wasn’t functional.

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