Question: Knowing that the genetic code is generally considered universal,
a scientist uses biotechnology t…
Knowing that the genetic code is generally considered universal,
a scientist uses biotechnology to insert a human DNA gene for
beta-globin into E. coli cells. He is certain that the bacterial
cells will express and synthesize functional beta-globin.
Beta-globin is one of the proteins used to form the oxygen-carrying
hemoglobin protein (a quaternary structure) and could be used to
help patients with abnormal hemoglobin. Instead, the protein
produced by the bacteria is larger and non-functional. Upon further
investigation it was found to have a different shape with a
different sequence of amino acids than the normal protein.
With your knowledge of DNA, the genetic code, and
protein synthesis, try to explain why the proper human gene for the
beta-globin that was inserted into the bacteria might not have
produced the correct shape and sequence of amino acids and why the
protein formed wasn’t functional.