Question: Introduction Many researchers are looking for the genetic causes of Alzheimer’s disease. In the 2…


Introduction Many researchers are looking for the genetic causes of Alzheimers disease. In the 2017 paper Candidate SNP Markers of Familial and Sporadic Alzheimers Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters, rescarchers were looking for mutations in the TATA boxes of different genes that may increase the likelihood that someone develops Alzheimers disease. The researchers did this by looking for known mutations in promoters of genes that have been associated with Alzheimers disease and testing some of them to see if the mutations changed the binding of transcription factors or the expression of the genes controlled by these promoters. 1. Identifying consensus sequences When scientists are trying to identify a consensus sequence, they can use one of several techniques to identify the sequences bound by the protein of interest. For example, a TATA box is bound by a TATA-binding protein. A scientist has used an experiment to identify the following sequences bound by TATA-binding protein: ATATAA GTATCA CTAGAA TTATAT ATTTAA TTATAA GTACAT CTATAA What is the consensus sequence? How do you explain what you observe in the first position of the binding sequence?

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Introduction Many researchers are looking for the genetic causes of Alzheimer's disease. In the 2017 paper "Candidate SNP Markers of Familial and Sporadic Alzheimer's Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters," rescarchers were looking for mutations in the TATA boxes of different genes that may increase the likelihood that someone develops Alzheimer's disease. The researchers did this by looking for known mutations in promoters of genes that have been associated with Alzheimer's disease and testing some of them to see if the mutations changed the binding of transcription factors or the expression of the genes controlled by these promoters. 1. Identifying consensus sequences When scientists are trying to identify a consensus sequence, they can use one of several techniques to identify the sequences bound by the protein of interest. For example, a TATA box is bound by a TATA-binding protein. A scientist has used an experiment to identify the following sequences bound by TATA-binding protein: ATATAA GTATCA CTAGAA TTATAT ATTTAA TTATAA GTACAT CTATAA What is the consensus sequence? How do you explain what you observe in the first position of the binding sequence?

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