Question: Each of the following plots compares the reaction of an enzyme with substrate in the presence or …


Each of the following plots compares the reaction of an enzyme with substrate in the presence or absence of different reversible inhibitors. Calculate and write your best estimates of the apparent values of Vmax and Km next to each plot. What case of reversible inhibition is represented in each case. Given that the in inhibitor concentration is 10 μM in each case calculate an estimates of the inhibibitor equilibrium dissociation constants Ki and/or Kifor the case of inhibition 30 25 20 30 25 2 15 10 -0.1 0.05 0.1 0.15 0.1 -0.05 0 0.05 0.1 0.15 -5 SVuM 20 15 10 0. -0.05 0 0.05 0.1 0.15

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Each of the following plots compares the reaction of an enzyme with substrate in the presence or absence of different reversible inhibitors. Calculate and write your best estimates of the apparent values of Vmax and Km next to each plot. What case of reversible inhibition is represented in each case. Given that the in inhibitor concentration is 10 μM in each case calculate an estimates of the inhibibitor equilibrium dissociation constants Ki and/or Ki'for the case of inhibition 30 25 20 30 25 2 15 10 -0.1 0.05 0.1 0.15 0.1 -0.05 0 0.05 0.1 0.15 -5 SVuM 20 15 10 0. -0.05 0 0.05 0.1 0.15

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