Question: D) what is the hill coefficient n in the absence AND presence of
low carbon monoxide?
E) What is …


(C) While hemoglobin is generally specific for binding oxygen, one exception is the deadly gas carbon monoxide. Carbon monoxide can bind hemoglobin 210-times tighter than oxygen. High, saturating levels of carbon monoxide replace all the bound oxygern on hemoglobin in the blood, causing asphyxiation and death. However, even very low levels of carbon monoxide that are below saturation can be fatal. To understand why, the fractional saturation of hemoglobin in blood for oxygen was measured in the absence and presence of a low level of carbon monoxide, enough for carbon monoxide to occupy just half the oxygen-binding sites. Data from the experiment are in the table below. Graph the Hill plot of the table, and label axes. Empty columns in the table may be helpful for doing calculations Po2 (mm Hg) | 9 (without e (plus CO CO gas) 0.005 0.03 0.17 0.39 gas) 0.16 0.35 0.61 0.74 4 16 24

D) what is the hill coefficient n in the absence AND presence of
low carbon monoxide?

E) What is tP50 (or K0.5) in the absence AND presence of low
carbon monoxide?

F)  Explain why even a small amount of carbon monoxide
is fatal. In your answer, refer to the effect of carbon monoxide on
the conformation of hemoglobin, what any changes in the P50 and
Hill coefficient of hemoglobin mean, and what the consequences are
for oxygen delivery in the body.

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(C) While hemoglobin is generally specific for binding oxygen, one exception is the deadly gas carbon monoxide. Carbon monoxide can bind hemoglobin 210-times tighter than oxygen. High, saturating levels of carbon monoxide replace all the bound oxygern on hemoglobin in the blood, causing asphyxiation and death. However, even very low levels of carbon monoxide that are below saturation can be fatal. To understand why, the fractional saturation of hemoglobin in blood for oxygen was measured in the absence and presence of a low level of carbon monoxide, enough for carbon monoxide to occupy just half the oxygen-binding sites. Data from the experiment are in the table below. Graph the Hill plot of the table, and label axes. Empty columns in the table may be helpful for doing calculations Po2 (mm Hg) | 9 (without e (plus CO CO gas) 0.005 0.03 0.17 0.39 gas) 0.16 0.35 0.61 0.74 4 16 24

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