Question: Blood glucose is usually about 3 – 5 mM except after a meal when
it usually rises. A pancreatic b…


Blood glucose is usually about 3 – 5 mM except after a meal when
it usually rises. A pancreatic beta-islet cell usually only
secretes insulin into the blood after a meal. Which of the
following observations best explains how a beta-islet cell senses
that a meal has been eaten?

A. The trans-membrane voltage potential of the beta-islet plasma
membrane increases dramatically and Ca++ is released.

B. The G-proteins of the glucose receptor on the plasma membrane
are activated and a signaling cascade causes insulin to be
released.

C. The Km of GLUT 2 for glucose is 17 mM.

D. Hexokinase is inhibited

E. Glucose 6-phosphate dehydrogenase is activated and glycolysis
is downregulated.

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