Question: BACKGROUND
The amino acid sequence for a protein that is associated with
the onset of Huntington’…


BACKGROUND

The amino acid sequence for a protein that is associated with
the onset of Huntington’s Disease in humans is 582 amino acids long
and is provided below. This disease is autosomal dominant and
results in a prolonged degeneration of nerve cells in the
brain.

INSTRUCTIONS

1. For this assignment, use any method you determine most
feasible (i.e. programming in MATlab, R script, Crystal Ball,
Witchcraft/Hocus Pocus, etc.) to decipher the amino acid
composition of this protein and answer the 15 questions associated
with this protein and its associated amino acid structure.

2. You will be calculating proportions (percentages – %) for
this assignment. Calculate all proportions to 1 decimal place and
make sure you have rounded up or down correctly. If unsure, use a
spreadsheet program such as Excel to display your proportional
calculations to 1 decimal place.

3. Spelling matters (Incorrect spelling will be
graded as such – incorrect).

5. Download/copy the sequence and review the questions so you
can double check your numbers before proceeding through the
homework.

Huntington Disease Associated Protein Amino Acid
Sequence

The first amino acid below (‘m’) represents the amino (NH3)
terminus of this protein. The last amino acid in this sequence
represents the carboxy (COOH) terminus and is the very last ‘c’ at
the bottom of this protein sequence structure. The amino acids are
numbered individually across the rows (left to right) beginning
from the amino terminus (#1) to the carboxy terminus (#582).

mvskreniat

hhlyqawdpv

pslspattga

lisheklllq

inperelgsm

syklgqvsih

svwlgnsitp

lreeewdeee

eeeadapaps

spptspvnsr

khragvdihs

csqfllelys

rwilpsssar

rtpailisev

vrsllvvsdl

fternqfelm

yvtltelrrv

hpsedeilaq

ylvpatckaa

avlgmdkava

epvsrllest

lrsshlpsrv

galhgilyvl

ecdllddtak

qlipvisdyl

lsnlkgiahc

vnihsqqhvl

vmcatafyli

enypldvgpe

fsasiiqmcg

vmlsgseest

psiiyhcalr

glerlllseq

lsrldaeslv

klsvdrvnvh

sphramaalg

lmltcmytgk

ekvspgrtsd

pnpaapdses

vivamervsv

lfdrirkgfp

cearvvaril

pqflddffpp

qdimnkvige

flsnqqpypq

fmatvvykvf

qtlhstgqss

mvrdwvmlsl

snftqrapva

matwslscff

vsastspwva

ailphvisrm

gkleqvdvnl

fclvatdfyr

hqieeeldrr

afqsvlevva

apgspyhrll

tclrnvhkvt

tc

CARBOXY TERMINUS

I posted this before with no replies! It’s urgent.

I need this decoded because I don’t have any access to any
coding methods in order to answer the following questions:

a.) a.) What is the name of the least abundant amino acid in
this protein?

b.) What proportion of the total amino acids in the protein does
this individual amino acid represent?

c.) What is the proportion of essential amino acids included in
this protein sequence?

d.)The amino acid sequence from residues 73-85 is represented by
the amino acids EEEWDEEEEEEAD, how would you generally classify
this small region of the protein? Choose from: neutral,
hydrophilic, hydrophobic, negatively charged, positively
charged

e.)Two amino acids are present in the same proportion in this
protein, which two are those?

f.)Which class of amino acids is the most abundant in this
protein?

g.) What amino acid(s) is/are present at locations 572 and 582
in the Huntington Disease protein (Full Amino Acid Name(s)).

h.)What type of structure could form between these amino acids
that could help stabilize this protein’s structure?

i.) Which class of amino acids is least abundant in this
protein?

j.)Summed together, how many hydrophilic amino acid residues are
present in this protein?

(Visited 1 times, 1 visits today)
Translate ยป