Question: AaBbcct AaB AaBbcet AaBbca JK 2 1 Normal 1 No Spac… Heading 1 Heading2 Title Subtitle Subtle Em…


AaBbcct AaB AaBbcet AaBbca JK 2 1 Normal 1 No Spac... Heading 1 Heading2 Title Subtitle Subtle Em JK! Styles Assignment for PK model Table 1 shows the plasma concentration-time profile of a drug after a single intravenous administration of the drug with a dose of 100 mg. Use compartment models that are pre- defined (in the PK library) in Simbiology to fit the data: 1) One-compartment, 2) Two- compartment model and 3) Three-compartment model. Evaluate which compartment r best represents observed pharmacokinetic data. Plot all results 1. 2. Estimate C, Ke, and Cl for each compartment model One- compartment Two-compartment Three-compartment model model 1st compartment:1t compartment: Clearance | (CI), volume(C) CF Cl- 2nd compartment 2nd compartment: Cl= C- 3rd compartment: 1st compartment: ke C- 1st compartment: Elimination Ke Rate (Ke), C Vol(C) Ke C- Ke= 3rd compartment: 2nd compartment 2ndcompartment: Ke=

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AaBbcct AaB AaBbcet AaBbca JK 2 1 Normal 1 No Spac… Heading 1 Heading2 Title Subtitle Subtle Em JK! Styles Assignment for PK model Table 1 shows the plasma concentration-time profile of a drug after a single intravenous administration of the drug with a dose of 100 mg. Use compartment models that are pre- defined (in the PK library) in Simbiology to fit the data: 1) One-compartment, 2) Two- compartment model and 3) Three-compartment model. Evaluate which compartment r best represents observed pharmacokinetic data. Plot all results 1. 2. Estimate C, Ke, and Cl for each compartment model One- compartment Two-compartment Three-compartment model model 1st compartment:1t compartment: Clearance | (CI), volume(C) CF Cl- 2nd compartment 2nd compartment: Cl= C- 3rd compartment: 1st compartment: ke C- 1st compartment: Elimination Ke Rate (Ke), C Vol(C) Ke C- Ke= 3rd compartment: 2nd compartment 2ndcompartment: Ke=

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