Question: 2. Consider the standard genetic code in Escherichia coli
(above). The number to the right of eac…


Codon AA % Codon AA % Codon AA % Codon AA % Phe 1.9 TCT Ser 1.11 TAT Tyr 1.6 TGT Cys 0.4 T TTA Leu 1.0TCA Ser0.7 TAA Stop 0.2 TGA Stop 0.1 A TTG Leu . TCG Ser0.8 TAG Stop 0.03TGG Trp CTG Leu 5.2 CCG Pro 2.4 CAG GIn 2.9 CGG Ar 2.7 ACC Thr 2.4 AAC Asn 2.6AGC Ser GTC Val 1.4 | GCC Ala 2.3| GAC Asp 2.3 | GGC Gly 3,0| C GTA Val 1.GCA Ala 2.1 GAA Glu 4.4 GG Gly 0.7A 6 Data shown in this table are from the Arabidopsis Research Companion (weeds.mgh.harvard.edu)

2. Consider the standard genetic code in Escherichia coli
(above). The number to the right of each codon indicates its
relative usage throughout the entire genome, in percent. For
example, TAG occurs at 0.03% of all codon positions in the E. coli
genome.

a) Aside from the TAG codon utilized in the Lajoie et al.
article, what four codons do you think would be most amenable to
genomic recoding? Explain your reasoning.

b) What four codons do you think would be poor choices for
genomic recoding? Explain your reasoning.

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Codon AA % Codon AA % Codon AA % Codon AA % Phe 1.9 TCT Ser 1.11 TAT Tyr 1.6 TGT Cys 0.4 T TTA Leu 1.0TCA Ser0.7 TAA Stop 0.2 TGA Stop 0.1 A TTG Leu . TCG Ser0.8 TAG Stop 0.03TGG Trp CTG Leu 5.2 CCG Pro 2.4 CAG GIn 2.9 CGG Ar 2.7 ACC Thr 2.4 AAC Asn 2.6AGC Ser GTC Val 1.4 | GCC Ala 2.3| GAC Asp 2.3 | GGC Gly 3,0| C GTA Val 1.GCA Ala 2.1 GAA Glu 4.4 GG Gly 0.7A 6 Data shown in this table are from the Arabidopsis Research Companion (weeds.mgh.harvard.edu)

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